DIMETHY SULFOXIDE MATERIAL SAFETY DATA SHEET
1 . PRODUCT AND MANUFACTURE
Product Name: Dimethyl Sulfoxide
Chemical Name: Dimethyl Sulfoxide
Molecular Formula: (CH3)2SO
Molecular Weight: 78.13
Manufacturer: PANJIN XINXING CHEMICAL PLANT
XINXING TOWN, DAWA COUNTY, PANJIN CITY,
LIAONING PROVINCE, CHINA
TEL: +86-427-6813221£¬7868818(8:00am - 5:00pm CST)
+86-427-6811449(Night)
+86-427-6811436(Weekends)
2 . COMPOSITION INGREDIENTS
Materials: Dimethyl Sulfoxide
CAS No.: 67-68-5
Weight: 99.8%min
3 . HAZARDS INDENTIFICATION
WARNING! COMBUSTIBLE LIQUD AND VAPOR
PHYSICAL APPEARANCE: Clear liquid
ODOR: Essentially odorless
EFFECTS OF OVEREXPOSURE:
General:
Dimethyl Sulfoxide has shown very few toxic symptoms in humans.
The most common are nausea, skin rashes and an unusual garlic-
onion-oyster smell on body and breath.
Inhalation:
High vapor concentrations may cause headache, dizziness, and
sedation.
Eyes:
Low hazard for usual industrial handling or chemical handling by
trained personel.
Skin:
Stinging and burning of the skin as well as rashes and vesicles have
been seen. A heat reaction may occur if applied to wet skin. Avoid
contact with DMSO solutions containing toxic material or materials
whose toxicological properties are not known since DMSO may penetrate
the skin under certain conditions and may carry such materials into
the body.
Ingestion: Expected to be a low ingestion hazard.
4 . FIRST AID MEASURES
NOTE:
Never give fluids or induce vomiting if patient is unconscious or is having
convulsions.
General Advice:
Remove contaminated clothing promptly (launder before reuse).
Skin Contact:
Wash contaminated skin with water. See a doctor if irritation
persists.
Ingestion: Do not induce vomiting. Do following the doctor¡¯s advise.
Inhalation:
Remove the victim to fresh air. If breathing has stopped, provide artificial
respiration. Keep the victim warm and take the patient to hospital.
5 . FIRE-RIGHTING MEASURES
Combustible Liquid
Flash Point and Method:
89¡æ(192¨H) closed cup
95¡æ(203¨H)open cup
Flammable Limits (% in air):
LEL: 3.0-3.5% by volume
UEL: 42-63% by volume
Auto ignition Temperature: 300-302¡æ(572-575¨H)
Extinguishing Media: Foam, carbon dioxide, dry powder, water spray.
Special Protective Equipment for Fire-fighters:
wear a self contained breathing apparatus.
Special Exposure Hazards:
Burning dimethyl sulfoxide produces poisonous gases (sulfur oxides). Wear
gloves, self-contained breathing apparatus, and rubber suit.
Spill, Leak, or Release:
Note: Review sections 3, 4, and 5 of this MSDS before proceeding with clean
up. Use appropriate personal protective equipment during clean up.
6 . ACCIDENTAL RELEASE MEASURES
Personal Precautions:
In case of mist formation use a respirator.
Environmental Precautions:
If a spill or leak occurs, immediately consult the environmental supervisor.
Remove ignition sources. Ventilate the area. Do not breathe the vapor or
get liquid in eyes or on skin/clothing.
Spill Clean-up Methods: Waterways.
7 . HANDLING AND STORAGE
Usage/Handling Precautions:
Keep away from sources of ignition. Do not smoke. Do not breathe vapor or
mist. Avoid contact with skin, eyes, or clothing.
Storage Precautions:
Keep container tightly closed in a well ventilate place. Freezes
(solidifies) at 18.3¡æ(65¨H).
8 . EXPOSURE CONTROLS/PERSONAL PROTECTION
Ventilation:
Good general ventilation (typically 10 air changes per hour) should be
matched to conditions. Use process enclosures, local exhaust ventilation,
or other engineering controls to maintain ventilation.
Respiratory Protection:
In case of mist formation use a respirator. Respirator type: organic vapor.
Eye Protection:
Tightly fitting safety goggles.
Recommended Decontamination Facilities:
Eye bath, washing facilities.
9 . PHYSICAL AND CHEMICAL PROPERTIES
Physical Form: liquidColor: colorless
Odor: essentially odorless
Odor Threshold: not available
Specific Gravity: 1.101 at 20¡æ(68¨H)(water=1)
Vapor Pressure: 0.55 mbar (0.46 mmHg) @ 20¡æ(68¨H)
Vapor Density (Air=1): 2.7
Evaporation Rate (n-butyl acetate=1): 0.026
Melting Point: 18.3¡æ(65¡æ)
Viscosity at 25¡æ (77¨H): 2.0mPa.s or cP
Solubility in water at 20¡æ: miscible
Octanol/Water Partition Coefficient: logP=-1.35
Sensitivity to Static Discharge:
Material is unlikely to accumulate a static charge which could act as an
ignition source.
Flash point and method:
89¡æ (192¨H) closed cup
95¡æ (203¨H) open cup
Flammable Limits (in air):
LEL: 3.0-3.5 % by volume
UEL: 42-63 % by volume
Auto-ignition Temperature: 300-302¡æ (572-575¨H)
10. STABILITY AND REACTIVITY
Stability: Stable
Conditions to avoid: Prolonged heating above 150¡æ
Materials to avoid:
Organic and inorganic acid chlorides, strong oxidizing agents, alkali
metals, hydrobromic acid, acidic solutions of alkali bromides.
Hazardous Decomposition Products:
Sulfur dioxide, formaldehyde, methyl mercaptan, dimethyl sulfide, dimethyl
disulfide.
Hazardous Polymerization: will not occur.
11. TOXICOLOGICAL INFORMATION
Data for Dimethyl Sulfoxide:
Acute Toxicity Data:
Oral LD-50 (male rat): 14,500-28,300 mg/kg
Inhalation (rat): No mortality rate @ 2,900 mg/m3(900ppm)/24hrs
Dermal LD-50 (rat): 40,000 mg/kg
Skin Irritation (human): Mild
Repeated Skin Application (human): Slight irritation
Subchronic Toxicity Data:
Oral Study (13 weeks, rat):
LOEL (lowest observed effect level)=8,800 mg/kg/day
Minor target organ effects: liver
Reduced body weight gain: NOEL (no observed effect level)=1,100 mg/kg/day
Inhalation Study (6 weeks, rat): NOEL=60ppm
12. ECOLOGICAL INFORMATION
Introduction:
This environmental effect summary is written to assist in addressing
emergencies created by an accidental spill which might occur during
shipmen or handling of this material. It is not meant to address discharges
to sanitary sewers or publicly owned treatment works.
Aquatic Toxicity:
The LC50 (96 hrs) for ten species of fish range from 32,500 to 43,000 ppm.
The LC50 for two species of protozoans is 32,000 and 38,000 ppm. The
concentration required to inhibit growth (EC50) for five species of
blue-green algae and one green algae species ranged from 0.4 to 4.0%. DMSO
is non-bio-accumulating since the log of the octanol/water partition
coefficient is ¨C1.35.
Phytotoxicity:
Soaking tomato, cucumber, and bean seeds for 18hrs in up to 8% DMSO solutions
had no effect on germination rate. DMSO has no effect on the growth rate
of corn when sprayed on at rates up to 136L/acre. When diluted with a large
amount of water, release of DMSO, directly or indirectly, to the
environment is not expected to have significant effect.
Biological Oxygen Demand:
Theoretical Oxygen Demand at 10ppm: 123mg oxygen
Chemical Oxygen Demand at 10ppm: 107mg/l
Biological Oxygen Demand-5 at 10ppm: <1.0mg/l
13. DISPOSAL CONSIDERATIONS
Disposal Methods
Water Disposal:
Dilute and flush to an approved wastewater treatment system. Bacterial
decomposition of dimethyl sulfoxide during wastewater treatment can
result in the release of dimethyl sulfide (a volatile substance with a
strong disagreeable odor). Waste DMSO can also be incinerated in an
approved furnace where permitted. Consult the center or local authorities
for proper disposal procedures. Should be transported/delivered using a
registered waste carrier for recycling or waste disposal in accordance
with local regulations.
14. TRANSPORT INFORMATION
Bulk (20.5MTS/container)
Proper Shipping Name: None
Hazards Class: None
I.D. No.: None
Packing Group: None
Report Quantity: N/A
Label(s): None
Quantity Limitations: None
Drum (¡Ü18.4MTS per container, 80 drums/container; 200kg/drum,
or 225kg/drum, or 230kg/drum)
Proper Shipping Name: Dimethyl Sulfoxide
Hazard Class: None
I.D. No.: None
Packing Group: None
ICAO-International Civil Aviation Organization Status: unregulated
IATA-International Air Transport Agency Status: unregulated
IMDG-International Marine Dangerous Goods Status: unregulated
15. REGULATORY INFORMATION
WHMIS (Canada) Ingredient Disclosure List: Listed
WHMIS9 (Canada) Status: Regulated
WHMIS (Canada) Hazard Classification: None
IARC-International Agency for Research on Cancer Carcinogenicity Classification
(Components present at 0.1% or more): Not listed
ATP-American Toxicology Program: Listed
TSCA-US Toxic Substance Control Act: Listed
EINEC-European Inventory of Existing Commercial Chemical Substances: Listed
AIC-Australian Inventory of Chemical Substances: Listed
Japanese Handbook of Existing and New Chemical Substances: Listed
xiuren-chen 27.11.2000
|
|
|
|
|
